Cytotoxic Activities of the Crude Venoms of Macrovipera lebetina lebetina from Cyprus and M. l. obtusa from Turkey (Serpentes: Viperidae) on Human Umbilical Vein Endothelial Cells
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چکیده
منابع مشابه
Paraspecificity of Vipera a. ammodytes-specific antivenom towards Montivipera raddei and Macrovipera lebetina obtusa venoms.
Antivenom raised against the venom of nose-horned viper, Vipera ammodytes (V. a.) ammodytes (European viper venom antiserum, Zagreb antivenom), contains neutralising equine F(ab')₂ fragments that are clinically successful against homologous venom, but also against the venoms of several others medically important European snakes due to its paraspecific action. In this work we demonstrated that Z...
متن کاملClinical, physiological and serological observations of a human following a venomous bite by Macrovipera lebetina lebetina (Reptilia: Serpentes).
A researcher, a 40 year-old male, was bitten on his finger accidentally by a 75 cm long, adult male blunt-nosed viper, Macrovipera lebetina lebetina (Linnaeus) that had been collected from northern Cyprus during laboratory work in the Zoology Section, Biology Department of the Ege University Faculty of Science. The clinical signs, physiological and biochemical changes soon after the venomous bi...
متن کاملA serological comparison of the populations of the Levantine Viper, Macrovipera lebetina (Linnaeus, 1758) in Cyprus and Southern Turkey
The present study compares the blood-serum proteins of populations of the Levantine viper, Macrovipera lebetina L. from Cyprus and southern Anatolia by polyacrylamide gel electrophoresis and densitometry analysis methods. There were discernible differences found between the two populations for the blood serum protein features compared. By considering these differences, it is concluded that the ...
متن کاملAnti-tumor effect investigation of obtustatin and crude Macrovipera lebetina obtusa venom in S-180 sarcoma bearing mice.
Over the last few decades, research on snake venom toxins has provided not only new tools to decipher molecular details of various physiological processes, but also inspiration to design and develop a number of therapeutic agents. Isolated from the venom of Macrovipera lebetina obutusa (MLO), obtustatin represents the shortest known snake venom monomeric disintegrin specific inhibitor of α1β1 i...
متن کاملCytotoxic Effect of Iranian Vipera Lebetina snake Venom on HUVEC Cells
Objective: Envenomation by heamotoxic snakes constituted a critical health occurrence in the world. Bleeding is the most sever consequence following snake bite with viperid and crothalid snakes. It is believed that the degradation of vascular membrane caused hemorrhage; in contrast, some suggested that direct cytotoxicity has role in endothelial cell disturbances. This study was to evaluate the...
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ژورنال
عنوان ژورنال: Commagene Journal of Biology
سال: 2019
ISSN: 2602-456X
DOI: 10.31594/commagene.655929